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KMID : 0381120060280040353
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Genes and Genomics
2006 Volume.28 No. 4 p.353 ~ p.360
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Discovery of single nucleotide polymorphisms in SLA-1 cDNA from Korean native pigs and phylogenetic analysis
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Kim Nam-Eun
Woo Chan-Jin
Choi Ho-Jun
Vijaya Ramu
Uhm Sang-Jun
Lee Hoon-Taek
Park Chan-Kyu
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Abstract
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Identification of new alleles of MHC genes has significant meaning due to their functional importance. The characterization of SLA molecules is also important to develop suitable pig breeds as basic research models for biomedical research including xenotransplantation experiments. We cloned the complete cDNAs of the SLA-1 gene from five Korean native pigs
and analyzed the DNA sequence polymorphism. From the sequence comparison with previously reported SLA-1 alleles, we found three new SLA-1 alleles. Three out of five animals were homozygous for the SLA-1 locus. The phylogenetic analysis showed that SLA-1 alleles from Korean native pigs clustered with those of miniature pigs. This study will provide
valuable information on the characteristics of MHC molecules of Korean native pigs and genetic diversity of MHC molecules in pigs.
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KEYWORD
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MHC, SLA-1, Korean native pig, genetic diversity, Asian pigs
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